GIARDIA

Giardia is a genus of anaerobic flagellated protozoan parasites of the phylum Diplomonada in the supergroup "Excavata" (named for the excavated groove on one side of the cell body) that colonise and reproduce in the small intestines of several vertebrates, causing giardiasis. Their life cycle alternates between an actively swimming trophozoite and an infective, resistant cyst. The genus was named after French zoologist Alfred Mathieu Giard.

CHARACTERISTICS

Like other diplomonads, Giardia have two nuclei, each with four associated flagella, and lack both mitochondria and a Golgi apparatus. However they are now known to possess mitochondrial relics, called mitosomes. These are not used in ATP synthesis the way mitochondria are, but are involved in the maturation of iron-sulfur proteins. The synapomorphies of genus Giardia include cells with duplicate organelles, absence of cytostomes, and ventral adhesive disc.

INFECTION AND SYMPTOMS

Giardia lives inside the intestines of infected humans or other animals. Individuals become infected through ingesting or coming into contact with contaminated food, soil, or water. The Giardia parasite originates from contaminated items and surfaces that have been tainted by the feces of an infected animal. The symptoms of Giardia, which may begin to appear 2 days after infection, include violent diarrhea, excess gas, stomach or abdominal cramps, upset stomach, and nausea. Resulting dehydration and nutritional loss may need immediate treatment. After 1-2 days of diarrhea, the opposite occurs, constipation for 4-7 days, still with acute gas production. The typical infection within an individual can be slight, resolve without treatment, and last between 2–6 weeks, although sometimes longer and/or more severe. Coexistence with the parasite is possible, symptoms fade, but one can remain a carrier and transmit it to others. Medication containing tinidazole or metronidazole decreases symptoms and time to resolution, albendazole is also used and has an anti-helmintic (anti-worm) property as well, ideal for certain compounded issues when a general vermicidal agent is preferred.

PREVENTION

Person-to-person transmission accounts for a majority of Giardia infections and is usually associated with poor hygiene and sanitation. Water-borne transmission is associated with the ingestion of contaminated water. In the U.S. outbreaks typically occur in small water systems using inadequately treated surface water. Venereal transmission happens through fecal-oral contamination. Additionally, diaper changing and inadequate hand washing are risk factors for transmission from infected children. Lastly, food-borne epidemics of Giardia have developed through the contamination of food by infected food-handlers.

GENOME

A Giardia isolate (WB) was the first diplomonad to have its genome sequenced. Its 11.7 million basepair genome is compact in structure and content with simplified basic cellular machineries and metabolism. Currently the genomes of several other Giardia isolates and diplomonads (the fish pathogens Spironucleus vortens and S. salmonicida) are being sequenced. A second isolate (the B assemblage) from humans has been sequenced along with a species from a pig (the E assemblage). There are 5000 genes in the genome. The E assemblage is more closely related to the A assemblage than is the B. A number of chromosomal rearrangements are present.

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